Patel Anar J.*, Shah Mamta B., Patel Mehul N
*Research Scholar, NIMS University, Jaipur, Rajasthan.
A B S T R A C T
The present study was carried out for phospholipid complexation with spray dried hydro alcoholic extract (SDHAE) of Phyla nodiflora Linn to improve oral solubility of the plant. Various chemical tests were performed on the extract and shown presence of various metabolites like amino acids, flavonoids, triterpenoids, glycosides, phenols, tannins etc. Plant SDHAE showed absorbance at 215 nm due to might be presence of triterpenoidUrsolic acid. The physicochemical investigations showed that the spray dried extract formed complex confirmed by FTIR, XRD and DSC with phosphatidylcholine. With reduced drug crystallinity and particle size, the phospholipid complex showed enhanced aqueous solubility. On the basis of the dissolution study & ex in-vivo absorption study, it might be concluded that the phospholipid complex may be considered as promising drug delivery system for improved absorption across the gastrointestinal tract for improving the bioavailability of the molecule.
Keywords: Phyla nodiflora extract, ursolic acid, Phosphatydil choline complex.