Wednesday , 19 September 2018

Design and In-vitro Characterization of Loperamide Chewable Tablets

Gampa Vijaya Kumar1, Dr.V.Anjaneyulu2, J. Mamatha3
1Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rangareddy, Telangana

2Professor, KGR Institute of Technology and Management, Rampally, Rangareddy, Telangana, India.
3KGR Institute of Technology and Management, Rampally, Rangareddy, Telangana, India

A B S T R A C T
In the present work Maize starch, Mannitol and Cross carmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F7 formulation showed maximum % drug release i.e., 97.11 % in 45 min hence it is considered as optimized formulation. The F7 formulation contains Crosscarmellose sodiumas super disintegrate in the concentration of 2 mg.
Keywords: Loperamide, Maize starch, Mannitol, Cross carmellose sodium

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