Design and Characterization of Mouth Dissolving Tablets of Zolmitriptan Using Novel Super Disintegrants

Hareesh Dara*, Ampati Srinivas
St John College of Pharmacy, Hasanparthy, Hanamkonda, Telangana, India

A B S T R A C T
The present study was carried out on Zolmitriptan Mouth dissolving tablets were prepared by direct compression method and different concentration super disintegrants like croscarmellose sodium, polyplasdone XL and Explotab were used in mouth dissolving tablets. A total of 9 formulations were prepared and evaluated for various pre and post compression parameters like angle of repose, bulk density, tapped density, carr’s index, hausner’s ratio, weight variation, hardness, friability, thickness, wetting time, water absorption ratio, drug content, in vitro disintegration time, in vitro drug release. The in vitro disintegration time of the optimized formulation (F4) of Zolmitriptan was found to be 7 sec. Release rate of drug was 97.54% within 10 minutes. FTIR studies showed good compatibility between drug and excipients.
Keywords: Zolmitriptan, croscarmellose sodium, polyplasdone XL, Explotab