About author :
Amir Khan*, Fouzia Ishaq, Deepti Malhotra
*Department of Biochemistry, Division of Life Science,
Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences & Research, Dehradun, India
Lipids when reacted with free radicals can undergo the highly damaging chain reaction of lipid peroxidation (LP) leading to both direct and indirect effects. Garlic (Allium sativum) is one of the most popular herbs used worldwide to reduce various risk factors associated with cardiovascular diseases. In this we investigated the efficacy of antioxidant and hypolipidemic agent Allium sativum by analyzing all the parameters in plasma lipoprotein lipids, TL, TC, TG, VLDL-C, LDL-C, non-HDL-C, MDA and in-vitro oxidizability of LDL, as investigated in oxidized cholesterol feeded rats treated with and without Allium sativum. All the plasma lipids parameters, TL, TC, TG, VLDL-C, LDL-C, non-HDLC and MDA levels were significantly increased in hyperlipidemic control rats. After 4 weeks administration of Allium sativum extract significantly reduced the overall oxidative burden and effectively ameliorated the above alteredparameters.
Key Words: Oxidized Cholesterol, Atherosclerosis, Hypolipidemic, Antioxidant, Allium sativum