Comparative Study on Effect of Natural and Synthetic Superdisintegrants in fast Dissolving Tablets of Metoprolol Tartrate

P. Mohan Vikas*, CH. Murali, P. Nagasri, Y. Bhargav
Department of Pharmaceutics, Mother Teresa Pharmacy College, Sathupally, Khammam -507303, India.

A B S T R A C T
Metoprolol Tartrate (MT) is used as an anti-hypertensive and also as an adjunct in the treatment of hyperthyroidism. Adult dose as conventional preparations is 25-100 mg daily in single or divided doses, as extended release 100-200 mg once daily. The bioavailability of the drug when formulated as conventional tablets is 40 %. The aim of the study is to prepare and evaluate Oral Disintigrating Tablets (ODT) of metoprolol Tartrate using super disintegrants- sodium starch glycolate, cross povidone and Treated Agar to observe the effect of various concentrations of super disintegrants on the release profile of tablets. Themain objective of the study is to formulate and evaluate orodispersible tablets of metoprolol tartrate with natural and synthetic, semisynthetic superdisintegrants. Various formulations of metoprolol tartrate were prepared by direct compression method using different ratios of natural superdisintegrant (Treated Agar,) and synthetic, semi synthetic superdisintegrants (Poly plasdone (Crospovidone), sodium starch glycolate,) at the concentrations ranging from 6%-12%. The drug and excipients compatibility study was performed by Stability studies at room temprerature to study the interaction between drug and excipients. The blend of all formulations were evaluated for various precompressional parameters such as angle of repose, bulk, tapped densities, compressibility index, Hausner’s ratio and the prepared tablets were evaluated for various parameters like weight variation, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time, content uniformity and in-vitro drug release. Formulations with treated agar have shown promising results compared to other formulations with semi synthetic superdisintegrants.
Keywords: Orodispersible tablets, Superdisintegrants, Treated Agar