Comparative Study of Sustained Release Matrix Tablets Containing Metformin Hydrochloride Prepared By Various Techniques

Dr. R. Srinivasan, M. Geetavani*, J. Kamal Chandra, Sk. Shakir Ahmad, D. Rajesh Kumar, B. Hema Chandra
Siddhartha Institute of Pharmaceutical Sciences, Jonnalagadda, Narsaraopet, Guntur, Andhra Pradesh, India.

A B S T R A C T
Diabetes Mellitus, a metabolic disorder of multiple etiologies, is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism that results from imperfections in insulin secretion, insulin action or both. Metformin Hydrochloride Fourteen formulations (WG1, WG2, WG3, WG4, WG5, WG6, WG7, DC1, DC2, DC3, DC4, DC5, DC6 and DC7) of varying constituents were prepared. The formulations were evaluated for precompression and post compression properties. The similarity factor of WG1 is high when comparing to other formulations so, it is more similar to that of marketed formulation. The study reveals that the extended release of Metformin Hydrochlorideis possible for choosing the xanthan gum (natural polymer) as matrix former also shows anomalous diffusion.
Keywords: Diabetes Mellitus, Metformin hydrochloride, hyperglycemia and xanthan gum