Saturday , 25 November 2017

Comparative Analysis of Different Brands of Diclofenac Sodium Extended Release Tablets Available in Pharmacies at Perambalur

R. Nivetha, Dr. K. Chandramohan, Dr. R. Nepolean, R. Mugilan, R. Solaimuthu, N. Gayathri, Barkat yousif Mohamed alamin ali
Thanthai Roever College of pharmacy, Perambalur, Tamilnadu, India

A B S T R A C T
The aim of the present study is to analyze the different brands of diclofenac sodium extended release tablets available in pharmacies at Perambalur. Diclofenac Sodium is an analgesic agent which is classified under Non steroidal anti-inflammatory drug (NSAIDs). It is the good drug of choice for the treatment of muscle aches, back aches, strains, sprains, dental pain, menstrual cramps, and sports injuries. It can also reduce pain, swelling, and joint stiffness caused by rheumatoid arthritis and osteoporosis. The diclofenac is the commonly prescribes drug to relieve pain. Currently various brands of diclofenac sodium are available in the local market. In case, there is lack in prescribed brand at the pharmacies in Perambalur, the alternative brand is essential to treat the patients. During this alternative, the efficiency and quality of the drug is important. Hence, there is the need to reveal the quality of different brands to ensure the safety of the patients. The comparative analysis was done under four different brands of diclofenac sodium available in pharmacies at Perambalur. These brands were tested through different parameters in accordance to the guidelines given in IP i.e. weight variation, hardness, friability, disintegration, dissolution, assay. The result shows that all the parameters (weight variation, hardness, friability, disintegration, dissolution, assay) are within the IP limits. We conclude that all the brands are in accordance with IP, therefore we can go for the alternative brand in diclofenac without any hesitation.
Keywords: Diclofenac sodium, enteric coated tablets, weight variation, hardness, friability, disintegration, dissolution, assay.

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