Singh Haribansh Narayan*, Saxena Shivangi, Yadav Ajit Kumar, Singh Sunil
Department of pharmaceutics,
Invertis Institute of Pharmacy, Invertis University, Invertis Village, NH-24, Bareilly, India.
Most physiological, biochemical, and molecular processes in healthy organisms display robust, considerable changes on a 24-hour schedule. The prima facia being that various hormones, neurotransmitters, and other intra body components, are secreted in different amounts at different events of the day. Like our body that has an inbuilt 24 hour cycle similarly some diseases also follow the circadian patterns like, hypertension, asthma, arthritis, depression, ulcer, allergic rhinitis, myocardial infarction,sleep disorders etc.These variations affect both the disease states and the plasma drug concentrations. Therefore, we must look forward for developing rational drug-delivery systems that can affect a target cell or organ system at that circadian rhythm and at the same time makes it possible to optimize desired therapeutic outcomes and minimize or avert adverse effects. Present review mentions details of various diseases that can be treated with the help of chronotherapy, potential drugs used for the chronotherapeutic formulations and the market formulations available.
Key words: Chronotherapeutics, circadian rhythm, chronotherapy