Monday , 21 January 2019

Category Archives: Pharmaceutical Chemistry and New drug design

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Male Antifertility Activity of Hydro-Alcoholic Stem and Leaf Extracts of Ecballium Elaterium on Male Wistar Rats

1Sarath Chandiran Irisappan, 2Jaya Kumar Annamalai* 1Professor, Sun Institute of Pharmaceutical Education and Research, Nellore, A.P, India-524346 2Research Scholar, PRIST University, Thanjavur, Tamilnadu, India- 613403 A B S T R A C T Objective: The objective was to investigate the male antifertility effect of hydro-alcoholic stem and leaf extracts of Ecballium elaterium on male Wistar rats. Methods: The animals were divided ... Read More »

RP-HPLC Method Development and Validaton for the Simultaneous Estimation of L-Methyl Folate and EscitalopramIn Bulk and Its Pharmaceutical Dosage Form

Guvvala Triveni, G. Dharmamoorthy* Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupati-517506, Andhra Pradesh, India ABSTRACT A simple, Accurate, precise method was developed for the simultaneous estimation of the L-methyl folate and Escitalopram in bulk and its pharmaceutical dosage form.Chromatographic separation was carried on Denali C18(150 x 4.6 mm, 5µ) column . Mobile phase consist of Phosphate buffer and ... Read More »

Stability Indicating RP-HPLC Method for Simultaneous Estimation of Lumacaftor and Ivacaftor in Bulk and Pharmaceutical Dosage Forms

Pasala Sandhya Mounika, Rameeja Pattan* Department of Pharmaceutical Analysis, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, Nellore ABSTRACT A simple, fast, accurate, precise, reproducible Stability indicating Reverse phase High performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of Lumacaftor and Ivacaftor in Bulk and pharmaceutical dosage form. Chromatographic separation was  done  by using Agilent Eclipse XDB-C8 column ... Read More »

Stability Indicating RP-HPLC Method for Simultaneous Estimation of Sofosbuvir and Velpatasvir in Bulk and Pharmaceutical Dosage Form

V. Hari Baskar, Ramesh Dhani*, P. Priyanka, M. Suchitra Department of Pharmaceutical Analysis, Ratnam Institute of Pharmacy, Pidathapolur, Nellore. ABSTRACT A simple, precise, accurate rp-hplc method has been developed and validated for the sofosbuvir and velpatasvir in bulk and pharmaceutical dosage form. This method was carried out by using Inertsil ODS-3(4.6 x 150mm, 5mm).  Mobile phase containing phosphate buffer (ph4.8): ... Read More »

Identification of Candidate Inhibitory Ligands from Allium cepa and Molecular Docking Against Trypanosma brucei Phosphoglycerate Kinase; The In-Silico Structure-Activity Relationship

S. Cosmas, O.A Durojaye*, R. O Asomadu, I. N Amorha, O. I Diyoke, G. A Osegbo Department of Biochemistry, University of Nigeria, Nsukka A B S T R A C T Trypanosoma brucei is a unicellular parasite causing African sleeping sickness in cattle and humans. Infection occurs when a vector tsetse fly bites a mammalian host. The fly injects the ... Read More »

Method Development and Validation of Acetazolamide Single Drug Molecule by Using UV Double Beam Spectrophotometer

Rameeja Pattan*, M. Charitha, M. Hemalatha, C. Lalitha, P. Pravallika, M. Vyshnavi, V. Sneha Priya Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore-524 346, Andhra Pradesh ABSTRACT This UV-spectrophotometric technique is quite simple, accurate, precise, reproducible, and sensitive. The UV method has been developed for quantification of Acetazolamide in tablet formulation. The validation procedure confirms that this is an appropriate ... Read More »

Synthesis of Some Novel Benzimidazole Derivatives & Evaluation of Their Antibacterial Activity

Jayakumar.A*, Ramesh Dhani, Sindhu.P, Ayesha.K, Keerthi. V, Rajeswari.P, Sukanya.P, Vijayadurga.P, Department of Pharmaceutical Chemistry, Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore District-524 346 ABSTRACT Benzimidazoles are heterocyclic compounds in which benzene is fused with five membered ring containing two hetero atoms. Both hetero atoms are nitrogen (N), which are present at non-adjacent position. It has broad spectrum ... Read More »

Docking Analysis of Potent Inhibitors Lipooxygenase as Potential Anti-Inflammatory Agents

C. Buvana a*, R. Sureshb, A. Sumathyc , Jothia a*aDeparment of Pharmaceutical chemistry, Grace college of Pharmacy, Palakkad, Kerala. bDepartment of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Chidambaram, Tamilnadu, India cDeparment of pharmaceutical chemistry, Prime college of pharmacy, Palakkad, kerala  ABSTRCT The present work adds to the efforts to obtain new synthetic 5-hydroxyflavone with potential biological activity. Five new ... Read More »

Cosmetics Emulsion from African Nutmeg Oil (Monodora Myristica): Formulation, Chemical Evaluation and Microbiological Analysis

Ezeuko Adaora Stella1*, Bamgboye Omolara Agbeke2, Ademosun Olabisi Theresa3, Okedere Adebola Priscillia4 Department of Industrial Chemistry, College of Science and Technology, Covenant University, PMB 1023, Km 10, Idiroko Road, Ota, Nigeria. A B S T R A C T Globally, adulterated skin care products have been on distribution in the cosmetic market which causes alot of skin infections which has become ... Read More »

Synthesis, Characterisation and Biological Activities of Oxadiazole Derivative

G. Nagaraju*1, Dr. Sunil Kumar Bainda*2 1Research Scholar, Department of Pharmaceutical Chemistry, OPJS University, Churu, Rajasthan 2OPJS University, Churu, Rajasthan A B S T R A C T Isatin chemically known as 1H-indole-2, 3-Dione. It   is a unique molecule possessing both amide and keto carbonyl groups. Isatin and its derivatives having several pharmacological actions. In the present study some Isatins ... Read More »

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