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Category Archives: Pharmaceutical Chemistry and New drug design

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Development and Characterization of Gastro Retentive In Situ Gel of ziprasidone Hydrochloride

Uma Rani Gandi1*, R. Nagaraju2 1R.B.V.R.R. Women’s College of Pharmacy, Barkatpura, Hyderabad, Telangana 2Sri Padmavathi Mahila university, Tirupathi. A B S T R A C T The present study aimed at development of Ziprasidone HCl (anti-psychotic agent) into a prolonged release oral dosage form to reduce the frequency of administration which is very difficult for psychic patients. Ziprasidone has poor ... Read More »

Simultaneous determination of Mo(VI) and W(VI) using Second order derivative spectrophotometry

Dr.Srinivas Jagarlapudi*1, Dr.V. Suryanarayana Rao2, A. Ravi Kumar3, Panchumarthi. Srinivas4, CH. Sunil Babu5 Obvez Labs Pvt. Ltd.  Plot No. 22 & 23, ALEAP Industrial Area, Pragathi Nagar, Hyderabad, Telangana-500090, India. A B S T R A C T A simple, selective and sensitive spectrophotometric method has been developed for the simultaneous determination of Molybdenum (VI) and tungsten (VI) using 3,4-dihydroxybenzaldehyde ... Read More »

Evaluation of Hepatoprotective Activity of Berberis Vulgaris on Azathioprine Induced Oxidative Stress in Rats

Gampa Vijaya Kumar1, Dr. Y. Sridhar2, M.Anitha3 1Professor and Head, Department of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2Professor, KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India. 3KGR Institute of Technology and Management, Kesara, Rangareddy, Telangana, India. Abstract Hepatotoxicity may be predictable or unpredictable. Predictable reactions typically are dose related and occur ... Read More »

Synthesis, Characterization and Biological Activities of Thiadiazole Derivative

G. Nagaraju*1, Dr. Sunil Kumar bainda*2 1Research Scholar, Department of Pharmaceutical Chemistry, OPJS University, Churu, Rajasthan 2Dr. Sunil Kumar, OPJS University, churu, Rajasthan A B S T R A C T Isatin (indole-2, 3-dione) is an endogenous compound, widely distributed in mammalian tissues and body fluids. Isatin chemically known as 1H-indole-2, 3-Dione. It   is a unique molecule possessing both amide ... Read More »

Male Antifertility Activity of Hydro-Alcoholic Stem and Leaf Extracts of Ecballium Elaterium on Male Wistar Rats

1Sarath Chandiran Irisappan, 2Jaya Kumar Annamalai* 1Professor, Sun Institute of Pharmaceutical Education and Research, Nellore, A.P, India-524346 2Research Scholar, PRIST University, Thanjavur, Tamilnadu, India- 613403 A B S T R A C T Objective: The objective was to investigate the male antifertility effect of hydro-alcoholic stem and leaf extracts of Ecballium elaterium on male Wistar rats. Methods: The animals were divided ... Read More »

RP-HPLC Method Development and Validaton for the Simultaneous Estimation of L-Methyl Folate and EscitalopramIn Bulk and Its Pharmaceutical Dosage Form

Guvvala Triveni, G. Dharmamoorthy* Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupati-517506, Andhra Pradesh, India ABSTRACT A simple, Accurate, precise method was developed for the simultaneous estimation of the L-methyl folate and Escitalopram in bulk and its pharmaceutical dosage form.Chromatographic separation was carried on Denali C18(150 x 4.6 mm, 5µ) column . Mobile phase consist of Phosphate buffer and ... Read More »

Stability Indicating RP-HPLC Method for Simultaneous Estimation of Lumacaftor and Ivacaftor in Bulk and Pharmaceutical Dosage Forms

Pasala Sandhya Mounika, Rameeja Pattan* Department of Pharmaceutical Analysis, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, Nellore ABSTRACT A simple, fast, accurate, precise, reproducible Stability indicating Reverse phase High performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of Lumacaftor and Ivacaftor in Bulk and pharmaceutical dosage form. Chromatographic separation was  done  by using Agilent Eclipse XDB-C8 column ... Read More »

Stability Indicating RP-HPLC Method for Simultaneous Estimation of Sofosbuvir and Velpatasvir in Bulk and Pharmaceutical Dosage Form

V. Hari Baskar, Ramesh Dhani*, P. Priyanka, M. Suchitra Department of Pharmaceutical Analysis, Ratnam Institute of Pharmacy, Pidathapolur, Nellore. ABSTRACT A simple, precise, accurate rp-hplc method has been developed and validated for the sofosbuvir and velpatasvir in bulk and pharmaceutical dosage form. This method was carried out by using Inertsil ODS-3(4.6 x 150mm, 5mm).  Mobile phase containing phosphate buffer (ph4.8): ... Read More »

Identification of Candidate Inhibitory Ligands from Allium cepa and Molecular Docking Against Trypanosma brucei Phosphoglycerate Kinase; The In-Silico Structure-Activity Relationship

S. Cosmas, O.A Durojaye*, R. O Asomadu, I. N Amorha, O. I Diyoke, G. A Osegbo Department of Biochemistry, University of Nigeria, Nsukka A B S T R A C T Trypanosoma brucei is a unicellular parasite causing African sleeping sickness in cattle and humans. Infection occurs when a vector tsetse fly bites a mammalian host. The fly injects the ... Read More »

Method Development and Validation of Acetazolamide Single Drug Molecule by Using UV Double Beam Spectrophotometer

Rameeja Pattan*, M. Charitha, M. Hemalatha, C. Lalitha, P. Pravallika, M. Vyshnavi, V. Sneha Priya Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore-524 346, Andhra Pradesh ABSTRACT This UV-spectrophotometric technique is quite simple, accurate, precise, reproducible, and sensitive. The UV method has been developed for quantification of Acetazolamide in tablet formulation. The validation procedure confirms that this is an appropriate ... Read More »

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