Thursday , 15 November 2018

Bilayered Buccal Tablets of Ondansetron Hydrochloride: II an In-vitro and Ex vivo Evaluation

J. Bhaskar1*, T. Ramchandar2, V.L.Narasaiah3
1Dept. of Pharmaceutics, Princeton Institute of Pharmaceutical Sciences, Hyderabad, Telangana, India.

2Dept. of Pharmaceutics , Mother Teresa college of Pharmacy, Ghatkesar, Hyderabad, Telangana India.
3Dept. of Pharmaceutics, Dr Samuel George Institute of Pharmaceutical Sciences, Markapur, A.P, India.

A B S T R A C T
Buccoadhesive tablets of Ondansetron hydrochloride (OH) were prepared using HPMC K4M and Carbopol 934 as mucoadhesive polymers and ethyl cellulose to act as an impermeable backing layer.  Twelve formulations were developed with varying concentrations of polymers. The formulations were prepared by direct compression and characterized by different parameters such as weight uniformity, content uniformity, thickness, hardness, disintegration, swelling index, in-vitro drug release studies, mucoadhesive strength, and ex vivo permeation study. The result of the in-vitro release studies and permeation studies through bovine buccal mucosa revealed that complexed Ondansetron gave the maximum release and permeation. Optimized formulation characterized by FT-IR, results showed no evidence of interaction between the drug and polymers.

Key words: Buccoadhesive tablet, mucoadhesion, Ondansetron hydrochloride, FT-IR

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