Thursday , 3 December 2020

Azithromycin β –cyclodextrin ocular films: Preparation and evaluation

Narendra V*, Hindustan Abdul Ahad, Tanveer DM, Janardhan Naik M 
PG Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
APOTHEKE-2014, 8 Nov 2014, Organized by Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India

Abstract
This research work was targeted to prepare Azithromycin ocular films by complexation with β-CD (Beta cyclodextrin) and evaluate the same. Release retardants viz., HPMC K4M and Ethyl Cellulose were used and Glycerin was adopted as permeability enhancer. Interactions of Azithromycin with excipients used were studied by Differential Scanning Calorimetry and Fourier Transform infrared spectroscopic studies. The prepared ocular films were evaluated for physicochemical parameters, in vitro release studies. The in vitro drug dissolution data was best fitted to zero order release modeling. The optimized formulation (F-5) was subjected for accelerated stability studies. The results revealed that Azithromycin has no negative incompatibility with the excipients used. The prepared ocular films gave satisfactory physicochemical characteristics, in vitro release characteristics. The optimized formulation reservedits physiognomies even after stability studies.
Keywords: Azithromycin, β-Cyclodextrin, Ocular films, evaluation

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