Friday , 29 March 2024

Anxiolytic activity of Murraya koenigii leaf extract in Mice

ABOUT AUTHOR
Krishna Prasad.D*1, S.N. Sri Harsha1, D. Yashwanth kumar1, K.S.S.N. Neelima1
Pacific College of Pharmacy, PACIFIC University, Udaipur, Rajasthan
*E-mail: [email protected]

Abstract
The objective of the present study was to evaluate the anxiolytic activity of Murraya koenigii (MK) leaf extract as well as its interaction with conventional anxiolytic drugs using elevated plus maze, Open field behaviour test  and Light Dark model in mice. Albino mice were treated with MK (100, 250 and 500 mg/kg, po), Diazepam as positive control (1 mg/kg, po). Effects were observed on (a) time spent on (b) number of entries into (c) number of stretch attend postures (d) number of head dips in arms of elevated plus maze and on duration of immobility in tail suspension test. Results showed that MK  significantly (P<0.05) and dose dependently increased proportionate time spent on and number of entries into open arms while decreased number of stretch attend postures and head dips in closed arms. Dose dependent and significant (P<0.05) anti-immobility effect was found in mice treated with MK. Combination of MK (75 mg/kg, po) with imipramine (5 mg/ kg, po) or fluoxetine (5 mg/kg, po) also produced significant (P<0.05) anxiolytic activity. It is concluded that MK possess potential anxiolytic and antidepressant activities and it enhances the anxiolytic and antidepressant activities of imipramine and fluoxetine.
Key words: Murraya koenigii (MK), Anxiolytic activity, elevated plus maze test, Open field behaviour test, Light Dark model.

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