Antinociceptive activity of methanolic extract of Cordia Subcordata Lam. (Boraginaceae) in animal models of nociception

C. Madhavi Latha*^1,2_, K. Bhaskar Reddy^3
1Research Scholar, Pacific University of Higher Education and Research University, Udaipur, Rajastan, India.
²Department of Pharmacology, Jagan’s College of Pharmacy, Nellore, Andhra Pradesh, India.
³Department of Pharmaceutics, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, India.

A B S T R A C T
Antinociceptive activity of methanolic extract of whole plant of cordial subcordata was studied by peripheral or non-narcotic model of nociception like formalin induced writing test and central or narcotic model like hotplate method. The methanolic extract of plant of the plant, administered orally and the standard drug produced significant analgesic activity in formalin induced writhing syndrome as compared to the vehicle treated control group. In the hot plate analgesic test, in cordia subcordata at different doses and the standard drug treated group. The plant possesses significant anti nociceptive property as evidenced in all animal models of nociception. It is possible through diverse mechanism that may involve both central and peripheral pathways. The preliminary phytochemical investigation revealed the presence of alkaloids, terpenoids, and tannins in the methanolic extract of cordial subcordata which may be responsible for its antinociceptive activity.
Keywords: Cordia Subcordata, hot plate, nociception, formalin, pain.