Wednesday , 23 August 2017

Antidiabetic Activity of Catharanthus Pusillus (murr.) G.don (apocynaceae) Aerial Parts in Alloxan Induced Diabetic Wistar Albino Rats

Yellanki Krishnaveni*, Rahmath Taha khatoon, Gulnaz Amthul Khuddus
Department of Pharmacognosy, Vathsalya College of Pharmacy, Bhongir, Nalgonda, Telangana–508116, India.

A B S T R A C T
The present study deals with anti-diabetic activity of Catharanthus pusillus (Murr.) G. Don (Apocynaceae) aerial parts in alloxan induced diabetic rats. Diabetes was induced by using alloxan monohydrate at the dose of 100 mg/kg body weight, to overnight fasted rats. Diabetes was confirmed by fasting blood glucose (FBG) levels, if it is more than 250 mg/dl considered as Diabetic. The methanol extracts of Catharanthus pusillus (Murr.) G. Don (Apocynaceae) aerial parts (MECP) were administered orally to diabetic rats at the doses 250 and 500 mg/kg body weight. The effect of MECP on diabetes was compared with the standard drug Glibenclamide. MECP shows significant reduction in blood glucose level in dose dependent manner. The results obtained from this study proved that the plant Catharanthus pusillus (Murr.) G. Don (Apocynaceae) would be useful in the management of diabetes.
Keywords: Catharanthus pusillus, Alloxan, Diabetes mellitus, Fasting blood glucose level.

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