K. Ramprasad*, Akula Sowjanya
Sree Chaitanya Institute of Pharmaceutical Sciences, L.M.D Colony, Thimmapur, Karimnagar, Telangana, India
A B S T R A C T
The anticonvulsant effect of Ethanolic extracts from the roots and leaves of Raphanus sativus on maximal electroshock (MES) or pentylenetetrazole (PTZ) in experimental animals examined in this study. This medicinal plant belongs to the Brassicaceae family and these are popularly used in the treatment of kidney stones, whooping cough, liver problems, constipation, dyspepsia, arthritis. The extract of raphanus sativus (orally) was administered in mice at the doses of 250 and 400 mg/kg the Leaf and Root Extract suppressed hind limb tonic extensions (HLTE) induced by MES and also exhibited protector effect in PTZ-induced seizures, at 250 mg/kg dose. Since the ethanolic extract of raphanus sativus decreases the occurrence of MES and PTZ convulsions, it is concluded that it interfere with gabaergic mechanism(s) to exert their anticonvulsant effect in addition it reveals the presence of flavonoid and vitamins, phenolic compounds attributed to their anti-convulsant action.
Keywords: Epilepsy, PTZ, Phenytoin