Monday , 20 January 2020

Analytical Method Development and Validation of Naratriptan in Bulk and Tablet Dosage form using UV Spectrophotometer

R. Chandra Sekhar*, S. Sandeep*, Shaik Faisal Ahmed*, V. Asha Ranjani
Marri Laxman Reddy Institute of Pharmacy, JNTU, Hyderabad, Telangana. India.

A B S T R A C T
Objective: To develop and validate an analytical method for quantitative determination of Naratriptan in bulk and tablet dosage form. Results: The Naratriptan shows absorption maxima at 224.20nm and obeyed Beer’s law in the range of 2-10µg/ml. The limit of detection and limit of quantitation were 9.75 and 29.55µg/ml respectively. Percentage recovery of Naratriptan for the proposed method ranged from 98.1% to 102.2%. Conclusion: It was concluded that the proposed method is simple, easy to apply, economical and used as an alternative to the existing Spectrophotometric method for the routine analysis of Naratriptan in pharmaceutical formulations.

Keywords: Naratriptan, UV Spectrophotometer.

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