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V. Aparna*, D. Sireesha, Dr. Vasudha bakshi
Department of Pharmaceutical Analysis and Quality assurance, Anurag group of institutions (Formerly Lalitha college of pharmacy), Hyderabad, Telangana, India
A B S T R A C T
A simple, Accurate, precise method was developed for the simultaneous estimation of the Aspirin and Atorvastatin calcium in Tablet dosage form. Chromatogram was run through Agilent C18, 4.6 mmx150mm, 5mm. Mobile phase containing Methanol and Phosphater buffer in the ratio of 70:30 was pumped through column at a flow rate of 0.8ml/min. Optimized wavelength for Aspirine and Atorvastatin was 254nm. Retention time of Aspirine and Atorvastatin calcium were found to be 2.972min and 3.548 min. %RSD of the Aspirine and Atorvastatin calcium were and found to be 0.24 and 0.28 respectively. %assay was obtained for Aspirin and Atorvastatin within the limits. LOD, LOQ values are obtained from Aspirin and Atorvastatin within the limits respectively.
Keywords: Aspirin, Atorvastatin , RP-HPLC
