Adverse Drug Reactions of Combinatorial Therapy of Vildagliptin and Insulin

E. Priya*¹, Dr. Mallika Jainu^2
1Research Scholar, Research and Development Centre, Bharathiar University, Coimbatore–641046, India
²Department of Biomedical Engineering, Sri Siva Subramaniya Nadar College of Engineering, Kalavakkam, Chennai -603110, India.

A B S T R A C T
The progressive nature of the type-2 diabetes makes it necessary for the diabetic patients to take insulin as add on therapy to oral antidiabetic agents in order to maintain adequate diabetic control. But the insulin therapy is very effective in controlling the hyperglycemia during fasting but it is not effectively reducing hyperglycemia postprandially. So these drawbacks can be overcome by taking or combining insulin with other oral antidiabetic agents like incretin based therapies like vildagliptin and it enhances glucagon counter regulation and also it increases the glucose sensitivity of both alpha and beta cells. The effectiveness of combining vildagliptin with insulin has been shown by decreasing A1C levels causing hypoglycaemia. But the adverse effects of vildagliptin and insulin can be seen in their effects on different biochemical parameters and histopathological changes in the pancreatic and brain tissues.
Keywords: Insulin, Vildalgliptin, hypoglycaemia, adverse effects