Wednesday , 23 August 2017

Aceclofenac: A Review

Rajiv Kumar*1, Parminder Nain1, Jatinderpal Singh2, Jaideep Bajaj2, R.K. Dhawan2, Gagan Shah2
1Department of Pharmacy, Maharishi Markandeshwar Universty, Mullana, Ambala, India
2Department of Pharmacy, Khalsa College of Pharmacy, Amritsar, India

A B S T R A C T
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac.
Keywords: Aceclofenac, Anti- inflammatory, Diclofenac, Cyclooxgenase, NSAIDs

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