Thursday , 6 August 2020

A Study on the Effect of Penetration Enhancer on Ketoprofen Emulgel

Krishnaveni Manubolu*1, Sujatha Byna1, Yanadaiah P2, Sreenivasulu Munna3Venkata Anudeep padavala1
1Department of Pharmaceutics, Narayana Pharmacy College, Chinthareddy Palem, Nellore-524002.
2Department of Pharmacy Practice, Narayana Pharmacy College, Chinthareddy Palem, Nellore-524002.
3Department of Pharmaceutical Chemistry, Narayana Pharmacy College, Chinthareddy Palem, Nellore-524002.

A B S T R A C T
Topical delivery gained popularity for the treatment of local skin disorders. Topical formulations have the potential to deliver the drug to the site of action and can achieve the therapeutic benefit. Apart from the delivery of drugs through the skin it can maintain the long residence time with the skin. Among the topical formulations emulgel emerged as a promising drug delivery systems for the delivery of hydrophobic drugs. Ketoprofen is a non-steroidal anti-inflammatory drug. It is widely used as analgesic for patients with rheumatic disease, joint disorders such as ankylosing spondylitis, osteoarthritis. The aim of this study was to formulate the ketoprofen topical emulgel formulation using sodium alginate and to evaluate the effect of penetration enhancer DMSO on the drug release. To overcome the two major problems of ketoprofen, it is an insoluble drug and has irritant effect on GIT lead to ulceration and bleeding-emulgel was formulated. The formulated emulgels were subjected evaluation in terms of physical stability, homogeneity, drug content, invitro drug release.
Keywords: ketoprofen, emulgel, anti-inflammatory, analgesic

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