G. Divya, B. Kumar*, M. Gobinath
Department of Pharmacy Practice, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur (M), Nellore, Andhra Pradesh, India-524346
A B S T R A C T
Cancer is a major public health concern globally; it is the most frequent cause of death in economically developed countries. The major risk factor for lung cancer is long-term exposure to tobacco use and is often viewed solely as a smokers having 80–90% of lung cancers. However, a significant number of patients with lung cancer have no history of smoking. Nonsmokers account for 10–15% of lung cancer cases and these cases are often attributed to a combination of genetic factors,radon gas, and asbestos and air pollution. Our study showed the median OS for the entire cohort was 10± 1.74 months (95% CI: 7.1-14.02). PFS of study population was 8 ± 1.45 months (95% CI: 5.149-10.85). Carboplatin was responsible for 30.3% of the total ADRs. The major ADRs associated with the use of Carboplatin were Anemia, Thrombocytopenia, Neutropenia and Leucopenia. Cisplatin was second commonest drug which caused 21.3% of adverse drug reactions. Causality assessment of ADRs was done by using Naranjo’s scale. According to the scale 66.3% of ADRs were found to be probable and 33.7% of ADRs were possible.
Keywords: Cancer, Smoking, air pollution, carboplatin, Nutropenia.