Saturday , 4 July 2020

A Simple UV Spectroscopic Method for the Determination of Tramadol HCl in Bulk and It’s Dosage Form

B. Famida*, S. Muneer, B. Mohammed Ishaq, Hindustan Abdul Ahad, T. Nuzhath
PG Department of Pharmaceutical Analysis, Balaji College of pharmacy, Ananthapuramu, Andhra Pradesh, India

Tramadol hydrochloride (TDL), is chemically [2-(dimethyl amino methyl)-1-(3-methoxyphenyl) cyclohexanol]. [1] It is a centrally acting analgesic, used for treating moderate to severepain, possesses agonist actions at the μ-opioid receptor and effects reuptake at the noradrenergic and erotonergic systems. It is also used to treat moderate to moderately severe pain and most types of neuralgia, including trigeminal neuralgia. [2,3] Literature survey reveals that, several spectrophotometric method [1-3]. TLC- densitometry [4], HPLC method [5-8], High Performance thin layer chromatography-densitometry [9], have been reported for the estimation of tramadol in pharmaceutical formulations. Few analytical methods were reported in literature for the determination of tramadol and other combination drugs which includes spectrophotometric method [10-16], spectrophotometric and spectrofluorimetric method [17].
Keywords: TDL, Distilled water, UV spectroscopy, ICH guidelines

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