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B. Famida*, S. Muneer, B. Mohammed Ishaq, Hindustan Abdul Ahad, T. Nuzhath
PG Department of Pharmaceutical Analysis, Balaji College of pharmacy, Ananthapuramu, Andhra Pradesh, India
APOTHEKE-2014, 8 Nov 2014, Organized by Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
Abstract
A simple, economic, accurate UV method was developed for the estimation of Naproxen (NPR) in bulk and tablet dosage form. Water was used as a diluent to dissolve NPR. The drug mixture was sonicated for 3mins for the enhanced solubility. The absorptions were observed at 262.0 nm, which was selected for the further analysis of NPR in bulk and its tablet dosage forms. The proposed method was validated according to ICH guidelines. The method showed high sensitivity with linearity range from 5 to 30 μg/ml (r2=0.9991) at 262.0 nm. The limit of detection (LOD) was found to be 0.67 and the limit of quantization (LOQ) was determined as the lowest concentration was found to be 2.24. The reports expressed that the proposed method was found to be simple, precise, accurate and rapid for the estimation of NPR in bulk and tablet dosage form using UV spectroscopy.
Keywords: Naproxen, Distilled water, UV spectroscopy, ICH guidelines
