Vadlamudi Manohar, R.V.S. Mounica, Saritha Chandra*, Dr. P. Venkatesh
Jagan’s college of Pharmacy, Jangala kandriga, SPSR Nellore, Andhra Pradesh, India
A B S T R A C T
Transdermal drug delivery (TDDS) is regarding application of drug on the skin surface so that it can permeate through the skin & reaches the systemic circulation at sufficient concentration to ensure therapeutic efficacy. Transdermal drug delivery system has multiple advantages over conventional system; TDDS offers sustained drug release, patient compliance, avoidance of first pass effect, ease of application and removal in case of toxicity as well as decrease in the side effects as compared with conventional therapy. Stratum corneum acts as a barrier that limits the penetration of substances through skin and limitation can be overcome by permeation enhancing techniques. A transdermal patch has several components such as, drug reservoir, adhesive layer, release control membrane, backing membrane and liner etc. This review article offer an overview of TDDS, its advantages over conventional dosage forms, Limitations, various components of transdermal patches, types of patches, and its methods of evaluation and the advancements done in this field.
Keywords: Transdermal drug delivery system, Transdermal patch, Skin, Penetration enhancer.