Wednesday , 29 March 2017

A Review on Solid Lipid Nanoparticles for Ocular Drug Delivery System

Yerikala Ramesh*1, Chandra Sekhar K.B2, Jayachandra Reddy P3
1Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) – 524346, Andhra Pradesh, India.
2Department of Pharmaceutical Chemistry, JNTUA – Oil Technological Pharmaceutical Research Institute, Ananthapuramu – 515001, Andhra Pradesh, India.
3Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Chadalawada Nagar, Renigunta Road, Tirupathi-517506, Andhra Pradesh, India.

Solid Lipid Nanoparticles consist of a solid lipid matrix which is ability to stabilize in a surfactants having particle size of 50- 1000 nm. The Solid lipid nanoparticles are the effective lipid based colloidal carriers which were introduced as an alternative to the conventional carriers such as SLNs based on synthetic polymers or natural macromolecules. It enhances the oral bioavailability of the low aqueous soluble drugs due to their potential to enhance gastrointestinal solubilization. To improve the therapeutic efficacy of the drugs having low bioavailability, as well as to reduce their effective dose requirement. The various proportions of gels are incorporated in SL Nanoparticles, Gel formation of nanoparticles applied on the eye based on the classification of drug it may various in action. Appropriate analytical techniques for the characterization of SLN like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of SLN route of administration and the in vivo fate of the carriers Applications with respect of routes of administration such as oral, parenteral, topical, pulmonary etc. These polysaccharides are renewable resources which are currently being explored intensively for their applications in pharmaceutical, cosmetics, biomedical, biotechnological, agricultural, food, and non-food industries.
Keywords: Solid lipid Nano particles, Ocular Drug delivery system, Insitu gels

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