K. Surendra*, P. Bhavana, P. Anusha, CH. Madhura Meenakshi, P. Himabindu
Rao’s College of Pharmacy, Chemudugunta, Venkatachalam, Nellore, Andhra Pradesh-524320
A B S T R A C T
Ocular drug delivery to the eye has one of the most challenging researches for formulation scientists to series of specified characteristics according to the physiological structure of the eye. Eye is a unique and challenging organ for therapeutic drug delivery on to the surface as well as in the interior part of the ocular structure. However, one of the major drawbacks associated with topical ocular drug delivery is the rapid and extensive precorneal loss caused by drainage in the extra ocular area and high tear fluid turnover. Ophthalmic drug delivery, probably more than any other route of administration, may benefit from the uniqueness of Nano-approaches -based drug delivery. The use of Nano carriers provides attractive replacements for topical ocular drug delivery, mainly because of their capacity to protect the encapsulated molecule, along with its facilitated transport to the different compartments of the eye. Additionally, nanostructures may offer the possibility of controlling drug delivery, thus being attractive vehicles for the treatment of some chronic ocular diseases like glaucoma, CMV retinitis, retinal neovascular-ization and dry eye disease.
Keywords: Ocular drug delivery, Eye, Precorneal, Nano carriers, Ocular diseases, controlling drug delivery