Navneet Kumar Verma*, J.N. Mishra, D.K. Vishwakarma, Gulzar Alam
Department of Pharmacy, Kailash Institute of Pharmacy and Management, GIDA, Gorakhpur, U.P. India-273209
A B S T R A C T
Nasal drug delivery system (NDDS) has been used as a substitute route for the systemic accessibility of drugs restricted to intravenous administration. This is due to the porous endothelial membrane, large surface area, high total blood flow, the avoidance of first-pass metabolism, and ready accessibility. The nasal administration of drugs, including various compound, peptide and protein drugs, for systemic medication has been widely investigated in recent years. Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in rapid systemic drug absorption. Several approaches are here discussed for increasing the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption. The article highlights the importance and advantages of the drug delivery systems applied via the nasal route, which have bioadhesive properties. Bioadhesive or more appropriately, mucoadhesive systems have been prepared for both oral and peroral administration in the past. The nasal mucosa presents an ideal site for bioadhesive drug delivery systems.
Keywords: NDDS, Drug administration, systemic medication