Nahar PS*, Patil HM, Thorat AP, Shah SH
Department of Physiology and Biochemistry, B.J. Medical College, Pune, India
It has been well postulated that acute stroke is associated with increase oxidative stress in the form of free radical generation.In order to prevent toxicity of free radicals, these should immediately get neutralized. The most important antioxidant that causes neutralization of these free radicals are superoxidase dismutase (SOD) and vitamin C. The aim of the present study was to compare blood levels of SOD and vitamin C in patients of stroke with that of healthy volunteers. Estimation of SOD and vitamin C was done in 30 cases and 30 controls by calorimetric method. We found statistically significant decrease in blood levels of SOD and vitamin C in patients of stroke as compared to that of healthy volunteers. We concluded that patients of stroke are at high risk of developing oxidative stress and its related toxic consequences. So while treating these patients extra emphasis should also be given on reduction of oxidative stress in the form of antioxidant supplementation.
Key words: stroke, oxidative stress, Superoxide dismutase, vitamin C